Product Overview Piperine is a pungent component found in black pepper in the Piper Nigrum family. This spice has a long history of Ayurvedic medicinal use as a restorative tonic. It is most well known for its ability to support other foods and herbs’ bioavailability in traditional herbal formulas. Much research has supported that it increases turmeric root’s bioavailability by 20 fold.Piperine extract, derived from black pepper fruit, has a long history of use dating back as far as 100 BC, as noted in ancient Sanskrit literature. Pepper was a prevalent spice used in the middle ages to help cover salt-cured meats’ taste. It was highly prized and was used as currency. To give you a small idea of how important black pepper was during the early Roman empire, 3000 pounds of black pepper were demanded along with gold, silver, and silk as a ransom to free Rome from the Huns. Due to the value of spices, it was well known that those that ruled the black pepper and spice trade, in general, ruled the world. Piperine has the ability to support the assimilation of food and herbs that are traditionally harder for the body to metabolize. It may help the inhibition of various enzymes responsible for breaking down nutrients. It may stimulate amino acid transporters in the intestine lining and prevent removing the cells’ nutrients. Hence, they are available for a more extended period of time. Finally, piperine may decrease activity in the intestines and possibly allow many active components to enter the bloodstream in larger quantities. Because of its stimulating effect, piperine has been shown to support the pancreas in releasing digestive enzymes to reduce food transit in the gut. The powerful result is the possible inhibition of certain substances’ rapid breakdown, allowing for better utilization by the body. This is a big reason why traditional herbal formulas almost always have pepper, black, or cayenne.Piperine has been shown to support brain health because of its ability to cross the blood-brain barrier and support other nutrients to do the same. It may support healthy beta-endorphin and serotonin levels, positively affecting one’s mood. It helps other nutrients to support brain health; it is well spoken of as a nourishing brain tonic. Some of the nutrients it has shown to directly affect include CoQ10, B6, Curcumin, Amino Acids, Selenium, Glucose. Some of the metabolizing enzymes affected by piperine are CYPLa1, CYP1b1, CYP1b2, CYP2e1, CYP34a, and a host of over the counter and prescription drugs. For clarification, when we speak of over the counter and prescription drugs, we are simply informing you to be aware of piperine’s ability to increase bioavailability. It may very well enhance their action.Based on a study done in the Journal of Food and Chemical Toxicology, piperine at various doses showed a positive effect on mood and overall positive cognitive improvements. It was concluded that piperine is powerful functional food for the brain. In another study in Planta Medica, piperine was coupled with curcumin to evaluate curcumin’s bioavailability in rats and healthy humans. The results were conclusive. When curcumin was given alone to the rats, moderate serum concentrations were achieved over a period of 4 hours. When piperine was added with the curcumin, the curcumin serum concentration increased for a 1-2 hour period. Time to maximum concentration was significantly increased while elimination, half-life, and clearance significantly decreased. When curcumin was given alone to humans, serum levels were either undetectable or very low. The addition of piperine produced much higher blood concentrations within 1 hour after ingestion. When taken with piperine, the bioavailability of curcumin increased by 2000%.Whether you use it as a supplement or as a part of your daily food intake, piperine from black pepper is a great choice not just to spice up your food but get the most nourishment out of it too. Make spices a daily part of your life as they are an easy way to get a blast of powerful nourishment. Some possible traditional uses of Piperine Extract Powder may include: May support a healthy, pain response May support healthy levels of beta-endorphins May support healthy serotonin & dopamine levels May support healthy adrenals May support a healthy gut Bio enhancement May support the production of pancreatic enzymes May support a healthy inflammation response Combating the formation of new fat cells Combating malabsorption and malnutrition May support a healthy histamine response May support brain health May support the transporting of other nutrients and herbs This product is 100% natural and minimally processed. Taste, smell, texture, and color may vary from batch to batch. CAUTION: Do not take with medication. Suggested Use: Take 10mg with any herb, nutrient, or spice mix, to support better nonavailability. Mixing Suggestions: To increase flavor and nutritional profile, combine with our organic turmeric, organic ginger, and organic cinnamon powders.Botanical Name: Piper Nigrum L Seed.Other Names: Pepper Extract.Parts Used: Black Pepper.Ingredients: Black Pepper Fruit Extract 40:1 (Yielding 95% Piperine).Origin: Grown and extracted in China. Packaged with care in Florida, USA.Lean Factor strives to offer the highest quality organically grown, raw, vegan, gluten-free, non-GMO products available and exclusively uses low-temperature drying techniques to preserve all the vital enzymes and nutrients. Our 95% Piperine Extract Powder passes our strict quality assurance, which typically includes testing for botanical identity, heavy metals, chemicals, and microbiological contaminants. offers 95% Piperine Extract Powder packaged in airtight stand-up, resealable foil pouches for optimum freshness. Once opened, just push the air out of the pouch before resealing it to preserve maximum potency. Keep your 95% Piperine Extract Powder in a cool, dark, dry place.